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Title

Full Genome Characterization of Respiratory Syncytial Virus Causing a Fatal Infection in an Immunocompromised Patient in Tunisia

Authors

Valentina Curini; Maurilia Marcacci; Salma Abid; Monia Ouederni; Awatef ElMoussi; Latifa Charaa; Wafa Achour; Ramzi Ouhichi; Latifa Maazaoui; Adriano Di Pasquale; Hakim ElGhord; Ahlem Gzara; Alessandro Ripani; Francesca Di Giallonardo; Cesare Cammà; Alessio Lorusso; Ilhem Boutiba-Ben Boubaker; Curini; Valentina; Marcacci; Maurilia; Abid; Salma; Ouederni; Monia; ElMoussi; Awatef; Charaa; Latifa; Achour; Wafa; Ouhichi; Ramzi; Maazaoui; Di Pasquale; Adriano; ElGhord; Hakim; Gzara; Ahlem; Ripani; Alessandro; Di Giallonardo; Francesca; Cammà; Cesare; Lorusso; Alessio; Boubaker; Ilhem Boutiba-Ben

Availability

Better title

Full Genome Characterization of Respiratory Syncytial Virus Causing a Fatal Infection in an Immunocompromised Patient in Tunisia

Source

MDPI (mdpi.com)

URL

https://www.mdpi.com/2076-0817/11/7/758

Date

2022-07-02

Description

Abstract

Human orthopneumovirus (HRSV) is a virus belonging to the Pneumovirus genus that causes lower respiratory tract infections (LRTI) in infants worldwide. In Tunisia, thousands of infants hospitalized for LRTI are found to be positive for HRSV but no whole genome sequences of HRSV strains circulating in this country are available thus far. In this study, five nasal swab samples collected at different time points from a three-month-old female baby with severe immunodeficiency that was hospitalized for acute bronchiolitis were investigated by next generation sequencing. The Tunisian sequences from this study originated from samples collected in 2021, belong to the ON1 genotype of HRSV-A, and are clustered with European sequences from 2019 and not from 2020 or 2021. This is most likely related to local region-specific transmission of different HRSV-A variants due to the COVID-19 related travel restrictions. Overall, this is the first report describing the whole genome sequence of HRSV from Tunisia. However, more sequence data is needed to better understand the genetic diversity and transmission dynamic of HRSV.

Keywords

categories = <i>Human orthopneumovirus</i>,next generation sequencing,whole genome,phylogenetic analysis,HRSV-A

Body

Full Genome Characterization of Respiratory Syncytial Virus Causing a Fatal Infection in an Immunocompromised Patient in Tunisia

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Pathogens

2022,

11(7), 758; https://doi.org/10.3390/pathogens11070758

Keywords:

Human orthopneumovirus; next generation sequencing; whole genome; phylogenetic analysis; HRSV-A

Figure 1

MDPI and ACS Style

Curini, V.; Marcacci, M.; Abid, S.; Ouederni, M.; ElMoussi, A.; Charaa, L.; Achour, W.; Ouhichi, R.; Maazaoui, L.; Di Pasquale, A.; ElGhord, H.; Gzara, A.; Ripani, A.; Di Giallonardo, F.; Cammà, C.; Lorusso, A.; Boubaker, I.B.-B. Full Genome Characterization of Respiratory Syncytial Virus Causing a Fatal Infection in an Immunocompromised Patient in Tunisia. Pathogens 2022, 11, 758. https://doi.org/10.3390/pathogens11070758

AMA Style

Curini V, Marcacci M, Abid S, Ouederni M, ElMoussi A, Charaa L, Achour W, Ouhichi R, Maazaoui L, Di Pasquale A, ElGhord H, Gzara A, Ripani A, Di Giallonardo F, Cammà C, Lorusso A, Boubaker IB-B. Full Genome Characterization of Respiratory Syncytial Virus Causing a Fatal Infection in an Immunocompromised Patient in Tunisia. Pathogens. 2022; 11(7):758. https://doi.org/10.3390/pathogens11070758

Chicago/Turabian Style

Curini, Valentina, Maurilia Marcacci, Salma Abid, Monia Ouederni, Awatef ElMoussi, Latifa Charaa, Wafa Achour, Ramzi Ouhichi, Latifa Maazaoui, Adriano Di Pasquale, Hakim ElGhord, Ahlem Gzara, Alessandro Ripani, Francesca Di Giallonardo, Cesare Cammà, Alessio Lorusso, and Ilhem B.-B. Boubaker. 2022. "Full Genome Characterization of Respiratory Syncytial Virus Causing a Fatal Infection in an Immunocompromised Patient in Tunisia" Pathogens 11, no. 7: 758. https://doi.org/10.3390/pathogens11070758

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