+-------MOD:V-ADV------+                                 
     +SUBJ:+--OBJ:V-N-+           |                                 
     |     |          |           |                                 
 IGF 1 increases activation of second intracellular signal pathway .
SUBJ:V-N (increase,1)
OBJ:V-N (increase,activation)
MOD:V-ADV (increase,second)