In CHO 7 cells not expressing hamster __NODE__ protein and overproducing __SP__ __NODE__ protein , a protein chimera composed of mutant hamster __NODE__ protein ( C terminal truncation 998 End with its transmembrane domain deleted ) and of a protein fragment ( aa sequence KDAS ) in CHO 7 cells not expressing hamster __NODE__ protein and overproducing __SP__ __NODE__ protein increases cleavage of __SP__ __NODE__ protein .