In CHO __NODE__ cells , hamster __NODE__ protein increases phosphorylation of mutant __SP__ __NODE__ protein ( deletion 310 554 with its phosphotyrosine binding domain and its pleckstrin homology ( PH ) domain retained C terminal truncation 899 End ) to phosphorylated ( S307 ) mutant __SP__ __NODE__ protein ( deletion 310 554 with its phosphotyrosine binding domain and its pleckstrin homology ( PH ) domain retained C terminal truncation 899 End ) .