In CV 1 cells overproducing __SP__ __NODE__ protein and __SP__ __NODE__ protein , __NODE__ causes little or no change in transcriptional activation of reporter gene containing a promoter fragment ( 1320 1581 ) containing a FXRE 1 from mutant __SP__ __NODE__ gene ( G1038A G1039A C1047T C1048T with its FXRE 2 mutated ) .