+---------COMP:V-N(In)--------+            +-----COMP:N-N(of)----+   
         +MOD_ATT:+         +MOD_ATT:N+-SUBJ:V-N+---OBJ:V-N--+              +MOD_AT+   
         |        |         |         |         |            |              |      |   
 In endothelial cells , __NODE__ protein(s) increases downregulation of __NODE__ mRNA .
MOD_ATT:N-ADJ (cell,endothelial)
MOD_ATT:N-ADJ (protein(s),__NODE__)
COMP:V-N(In) (increase,cell)
SUBJ:V-N (increase,protein(s))
OBJ:V-N (increase,downregulation)
COMP:N-N(of) (downregulation,mRNA)
MOD_ATT:N-ADJ (mRNA,__NODE__)