In HepG2 cells , __NODE__ increases transcriptional activation of a luciferase reporter gene with a core promoter from the __NODE__ gene and with a synthetic promoter containing a multiple copies ( 2 times ) __NODE__ response element ( 5 ' ATGTCAATGACCT 3 ' from the __NODE__ gene that is dependent on a protein protein complex consisting of __NODE__ and of __SP__ __NODE__ .