In __SP__ , binding of mutant __NODE__ protein ( N terminal truncation with its C terminal domain retained ) and mutant __NODE__(s) ( C terminal truncation 443 End N terminal truncation with its ligand binding domain retained ) is greater than binding of mutant __NODE__ protein ( N terminal truncation with its C terminal domain retained ) and mutant __NODE__(s) ( N terminal truncation with its ligand binding domain retained ) .