In __SP__ , mutant __SP__ __NODE__ gene ( homozygous knockout ) and mutant __SP__ __NODE__ gene ( homozygous knockout ) and mutant __SP__ __NODE__ gene ( homozygous knockout ) cause little or no change in hyperlipidemia of __SP__ that is increased by mutant __SP__ __NODE__ gene ( homozygous knockout ) and mutant __SP__ __NODE__ gene ( homozygous knockout ) .