Mutant __SP__ __NODE__ gene ( homozygous knockout ) in 32 week old __SP__ overproducing transgenic mutant __NODE__ protein and transgenic mutant PS 1 [__NODE__] protein ( deletion ) increases quantity of amyloid plaque in cerebral cortex from 32 week old __SP__ overproducing transgenic mutant __NODE__ protein and transgenic mutant PS 1 [__NODE__] protein ( deletion ) .