__NODE__ protein in HepG2 cells decreases transcriptional activation of a luciferase reporter gene with a synthetic promoter ( GTACGCTGTCACAGGTCACAGGTCACAGGTCACAGGTCAC ) that has a DR1 response element in HepG2 cells that is increased by 9 __NODE__ __NODE__ in culture medium and __NODE__ protein in HepG2 cells .