In a cell fraction from Cos 7 cells , binding of __SP__ __NODE__ protein and __SP__ __NODE__ protein and Vitamin D response element from __SP__ __NODE__ gene is the same as binding of __SP__ __NODE__ protein and mutant __SP__ __NODE__ protein ( G28S R30E T32S F34C with its loop domain 1 from __NODE__ finger domain 1 mutated ) and Vitamin D response element from __SP__ __NODE__ gene .