In Cos 7 cells overproducing __SP__ __NODE__ protein and __SP__ __NODE__ protein , a protein chimera composed of a protein fragment containing a nuclear receptor domain from __SP__ __NODE__ protein and of a protein fragment containing a transcription activation domain from HSV viral Vp16 protein in Cos 7 cells increases trans activation of a luciferase reporter gene with a synthetic promoter that has a __NODE__ response element .