In HepG2 cells , 17 beta __NODE__ decreases transcription of reporter gene with a DNA endogenous promoter ( 1557 41 ) from the mutant __SP__ __NODE__ gene ( G 977T T 976G C 975G A 974G G 973A G 972T T 970C G 968C T 967G C 966T with its ERE mutated ) that involves __NODE__ protein .