In __SP__ , a protein chimera composed of a protein fragment ( 1 760 ) containing a N terminal domain from __NODE__ protein and of a protein fragment ( 729 End ) containing a C terminal domain from __NODE__ protein decreases apoptosis of serum deprived brown pre adipocyte cell lines treated with __SP__ __NODE__ protein that is increased by mutant __SP__ __NODE__ [__NODE__] gene ( homozygous knockout ) .