Mutant __SP__ __NODE__ [__NODE__] gene ( homozygous knockout ) in __SP__ causes little or no change in phosphorylation of __SP__ __NODE__/__NODE__ [__NODE__] protein(s) in brown pre adipocyte cell lines to phosphorylated ( Y204 ) __SP__ __NODE__/__NODE__ [__NODE__] protein(s) that is increased by __SP__ __NODE__ protein .