Mutant __SP__ __NODE__ protein ( L370R with its ligand binding domain mutated ) in HepG2 cells causes little or no change in trans activation of PPRE ( 5 ' GGGGACCAGGACAAAGGTCA 3 ' from __SP__ __NODE__ [__NODE__] gene(s) in HepG2 cells that involves WY 14643 in culture medium and __SP__ __NODE__ protein in HepG2 cells .