Transgenic __SP__ __NODE__ protein in 40 week old __SP__ increases expression of __SP__ __NODE__ mRNA in atherosclerotic lesion from aorta of 40 week old __SP__ that involves mutant __SP__ __NODE__ 48 [__NODE__] gene ( homozygous knockout ) in 40 week old __SP__ and mutant __SP__ __NODE__ gene ( homozygous knockout ) in 40 week old __SP__ .