Transgenic __SP__ __NODE__ protein in 50 week old __SP__ decreases size of atherosclerotic lesion in aorta from 50 week old __SP__ that is increased by mutant __SP__ __NODE__ 48 [__NODE__] gene ( homozygous knockout ) in 50 week old __SP__ and mutant __SP__ __NODE__ gene ( homozygous knockout ) in 50 week old __SP__ .