25 hydroxycholesterol in cell culture and __NODE__ in cell culture decrease cleavage of __SP__ __NODE__ protein in CHO 7 cells not expressing hamster __NODE__ protein and overproducing a protein chimera composed of mutant hamster __NODE__ protein ( C terminal truncation 998 End with its transmembrane domain deleted ) and of a protein fragment ( aa sequence KDAS ) and __SP__ __NODE__ protein .