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Ingenuity189


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Phrase 28 - PMID ?

In a system of purified components , the affinity of binding of a soluble protein chimera composed of Immunoglobulin heavy chain protein(s) and of __SP__ __NODE__ protein and __SP__ __NODE__ protein is greater than or equal to the affinity of binding of __SP__ __NODE__ protein and monomeric soluble mutant __SP__ __NODE__ A protein ( deletion 474 703 with its __NODE__ type III domain 1 2 deleted and with its carboxy terminal domain and its CR domain and its linker domain 1 2 ( aa sequence __NODE__ ) and its loop domain 1 2 retained ) .


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                                                                                      +--------------------------------------------COMP:N-N(of)--------------------------------------------+                                                                                                                                                                                                                                                                                                                                                                 
                                                                                      +----------------------------------COMP:N-N(of)----------------------------------+                   |                                                                                                                                                                                                                                                                                                                                                                 
                                                                                      +------------------COMP:N-N(of)------------------+                               |                   |                                                                                      +------------------SUBJ:V-N------------------+                                                                                                                                                              +--------------SUBJ:V-N--------------+                         
                                                         +--------COMP:N-N(of)--------+                       +-------MOD_ATT:N-N------+                               +-------------OBJ:V-N-------------+                                                                        |            +-----MOD_ATT:N-ADJ-----+       |                                                                          +------------COMP:V-N(with)-----------+            +--------MOD_ATT:N-N-------+     +------SUBJ:V-N-----+                |                         
                                                         |            +-MOD_ATT:N-ADJ-+                       |         +-MOD_ATT:N-ADJ+               +-MOD_ATT:N-ADJ-+                   +---OBJ:V-N---+                                             +---COMP:N-N(of)---+       |            |        +-MOD_ATT:N-ADJ+       +----------OBJ:V-N---------+------COMP:N-N(with)------+-------OBJ:V-N------+                    +--MOD_ATT:N-ADJ-+            |    +-----MOD_ATT:N-N-----+     +---APPOS--+        +----------OBJ:V-N---------+OBJ:V-N+       
         +-SUBJ:V-N-+-OBJ:V-N-+-----APPOS-----+COMP:N-N(o+            |       +MOD_ATT+SUBJ:V_P+              |         |     +MOD_ATT:+               |       +MOD_ATT+           +MOD_ATT+       +SUBJ:+                                             |          +MOD_ATT+       |            |        |       +MOD_AT+SUBJ:V-+    +MOD_+---APPOS--+     |                   +MOD_AT+               +SUBJ+                    |        +MOD_ATT+            |    |              +MOD_AT+     |    +MOD_A+        |                +-OBJ:V-N-+ +SUBJ:+       
         |          |         |               |          |            |       |       |        |              |         |     |        |               |       |       |           |       |       |     |                                             |          |       |       |            |        |       |      |       |    |    |          |     |                   |      |               |    |                    |        |       |            |    |              |      |     |    |     |        |                |         | |     |       
 In a system of purified components , the affinity of binding of a soluble protein chimera composed of Immunoglobulin heavy chain protein(s) and of __SP__ __NODE__ protein and __SP__ __NODE__ protein is greater than or equal to the affinity of binding of __SP__ __NODE__ protein and monomeric soluble mutant __SP__ __NODE__ A protein ( deletion 474 703 with its __NODE__ type III domain 1 2 deleted and with its carboxy terminal domain and its CR domain and its linker domain 1 2 ( aa sequence __NODE__ ) and its loop domain 1 2 retained ) .
SUBJ:V-N (purify,system)
OBJ:V-N (purify,component)
APPOS (component,affinity)
COMP:N-N(of) (affinity,bind)
COMP:N-N(of) (bind,chimera)
MOD_ATT:N-ADJ (chimera,soluble)
MOD_ATT:N-N (chimera,protein)
COMP:N-N(of) (chimera,protein(s))
COMP:N-N(of) (chimera,protein)
COMP:N-N(of) (chimera,__NODE__)
SUBJ:V_PASS-N (compose,chimera)
MOD_ATT:N-N (protein(s),immunoglobulin)
MOD_ATT:N-ADJ (protein(s),heavy)
MOD_ATT:N-N (protein(s),chain)
MOD_ATT:N-ADJ (protein,__SP__)
MOD_ATT:N-ADJ (protein,__NODE__)
MOD_ATT:N-ADJ (__NODE__,__SP__)
OBJ:V-N (be,protein)
OBJ:V-N (be,__NODE__)
SUBJ:V-N (be,protein)
COMP:N-N(of) (bind,__NODE__)
MOD_ATT:N-ADJ (__NODE__,__SP__)
MOD_ATT:N-ADJ (__SP__,monomeric)
MOD_ATT:N-ADJ (__SP__,soluble)
MOD_ATT:N-ADJ (__SP__,mutant)
SUBJ:V-N (__NODE__,protein)
SUBJ:V-N (__NODE__,__SP__)
OBJ:V-N (__NODE__,@card@)
MOD_ATT:N-N (protein,a)
APPOS (protein,deletion)
COMP:N-N(with) (@card@,type)
MOD_ATT:N-ADJ (type,__NODE__)
OBJ:V-N (delete,type)
SUBJ:V-N (delete,2)
COMP:V-N(with) (delete,domain)
MOD_ATT:N-ADJ (domain,carboxy)
MOD_ATT:N-N (domain,terminal)
MOD_ATT:N-N (domain,CR)
MOD_ATT:N-N (domain,domain)
MOD_ATT:N-N (domain,linker)
APPOS (2,sequence)
MOD_ATT:N-N (sequence,aa)
SUBJ:V-N (__NODE__,2)
OBJ:V-N (__NODE__,1)
SUBJ:V-N (loop,2)
OBJ:V-N (loop,1)
OBJ:V-N (retain,1)
SUBJ:V-N (retain,2)