Mutant __SP__ __NODE__ gene ( heterozygous knockout ) in mutant __SP__ with a homozygous knockout of __SP__ __NODE__ increases phosphorylation of 46 kd __SP__ __NODE__ protein in aortic arch in mutant __SP__ with a homozygous knockout of __SP__ __NODE__ to 50 kd phosphorylated ( S239 ) __SP__ __NODE__ protein in aortic arch in mutant __SP__ with a homozygous knockout of __SP__ __NODE__ that is decreased by high __NODE__ diet ( with a treatment period of 2 months ) of female mutant __SP__ with a homozygous knockout of __SP__ __NODE__ .