Mutant __SP__ __NODE__ gene ( heterozygous knockout ) in mutant __SP__ with a homozygous knockout of __SP__ __NODE__ increases production of __NODE__ in descending aorta in mutant __SP__ with a homozygous knockout of __SP__ __NODE__ that is decreased by high __NODE__ diet ( with a treatment period of 2 months ) of female mutant __SP__ with a homozygous knockout of __SP__ __NODE__ .