Mutant __SP__ __NODE__ gene ( homozygous knockout ) in male __SP__ treated with __NODE__ and with agonist LG100268 and mutant __SP__ __NODE__ gene ( homozygous knockout ) in male __SP__ treated with __NODE__ and with agonist LG100268 decrease expression of __SP__ __NODE__ mRNA in mucosa from small intestine of male __SP__ treated with __NODE__ and with agonist LG100268 .