Mutant __SP__ __NODE__ gene ( homozygous knockout ) in newborn __SP__ causes little or no change in binding of __SP__ __NODE__ protein and __SP__ __NODE__ ( Pik3r ) protein(s) in confluent immortalized preadipocytes treated with __NODE__ and with __NODE__ and with __NODE__ protein and with __NODE__ and with __NODE__ from newborn __SP__ .