In JEG3 cells , SREBP 1a [__NODE__] protein causes little or no change in activation of reporter gene with a DNA endogenous promoter ( 334 314 ) from the mutant __SP__ __NODE__ gene ( C 248T G 247T with its __NODE__ response element mutated ) that has a GC box and a __NODE__ regulatory element that is not changed by __NODE__ protein(s) .