In nuclear extract from 220.0 day old fetal __SP__ parietal bone primary osteoblasts , binding of a DNA fragment ( CTAGGCAGCTACAACTGGCTGGCAGCTAG ) containing a E box motif ( 5 ' CAACTG 3 ' from __SP__ __NODE__ gene and protein is greater than binding of a DNA fragment ( CTAGGCAGCTAGCTCTGGCTGGCAGCTAG ) and protein .