In nuclear extract from HepG2 cells , a DNA fragment ( 5 ' GGGGACCAGGACAAAGGTCAAGCAGCCAT 3 ' containing a PPRE from __SP__ __NODE__ [__NODE__] gene(s) decreases binding of a DNA fragment ( 385 373 ) containing a DR1 from __SP__ __NODE__ gene and a protein protein complex consisting of __SP__ __NODE__ .