In a nuclear fraction from H 4 II E cells , binding of mutant promoter fragment ( G?C T?A T?G T?C T?A with its __NODE__ binding site mutated ) containing a __NODE__ response element 1 and a __NODE__ response element 2 and a __NODE__ binding site from __NODE__(s) and __NODE__ protein is the same as binding of promoter fragment ( CCACTGGCACACAAAATGTGCAGCCAGCA ) containing a __NODE__ response element 1 from __NODE__(s) and __NODE__ protein .