In a nuclear fraction from H 4 II E cells , binding of promoter fragment containing a Coup __NODE__ binding site and a __NODE__ response element 1 and a __NODE__ response element 2 and a __NODE__ binding site from __NODE__(s) and __NODE__ protein is greater than binding of mutant promoter fragment ( G?T A?C G?T G?T with its Coup __NODE__ binding site and its __NODE__ binding site mutated ) containing a Coup __NODE__ binding site and a __NODE__ response element 1 and a __NODE__ response element 2 and a __NODE__ binding site from __NODE__(s) and __NODE__ protein .