In a cell free system , binding of a DNA fragment ( 462 442 ) from mutant __SP__ __NODE__ gene ( G 454C T 453C A 451T with its IP9 vitamin D response element mutated ) and a heterodimeric protein protein complex consisting of __SP__ __NODE__ and of __NODE__ is greater than binding of a DNA fragment ( 458 442 ) containing a __NODE__ Vitamin D response element from __SP__ __NODE__ gene and a heterodimeric protein protein complex consisting of __SP__ __NODE__ and of __NODE__ .