In a cell free system , binding of a DNA fragment ( 5 ' AGGGTTCACCGAAAGTTCAGC 3 ' containing a RARE from __NODE__ gene and heterodimer consisting of __NODE__ and of __NODE__ is greater than or equal to binding of a DNA fragment ( 5 ' AGGGTTCACCGAAAGTTCAGC 3 ' containing a RARE from __NODE__ gene and heterodimer consisting of mutant __NODE__ ( C terminal truncation 383 End with its activation domain and its dimerization domain mutated ) and of __NODE__ .