In a cell free system , binding of promoter fragment ( CATTCTGGGTCAAAGTTGATCCCCT ) from __NODE__ gene(s) consisting of DR1 response element and a protein protein complex consisting of frog __NODE__ and of __SP__ __NODE__ is greater than binding of promoter fragment ( CATTCTGGGTCAAAGTTGATCCCCT ) from mutant __NODE__ gene(s) ( C?T A?C T?G C?A T?G ) consisting of DR1 response element and a protein protein complex consisting of frog __NODE__ and of __SP__ __NODE__ .