In a cell free system , the affinity of binding of promoter fragment from APOLIPOPROTEIN A II [__NODE__] gene consisting of __NODE__ response element and a protein protein complex consisting of __SP__ __NODE__ and of __NODE__ is greater than the affinity of binding of promoter fragment from APOLIPOPROTEIN A II [__NODE__] gene consisting of __NODE__ response element and a protein protein complex consisting of mutant __SP__ __NODE__ ( P12A ) and of __NODE__ .