In a system of purified components , binding of double stranded __NODE__ Vitamin D response element ( 5 ' AGCTTAAGAGGTCAGAAAGGTCACTCGCAT 3 ' and a protein fragment ( 613 752 ) containing a LXXLL motif 1 2 3 from __NODE__ protein and a protein protein complex consisting of __NODE__ and of __NODE__ and vitamin D is greater than binding of double stranded __NODE__ Vitamin D response element ( 5 ' AGCTTAAGAGGTCAGAAAGGTCACTCGCAT 3 ' and a mutant protein fragment ( 613 752 ) ( L688A L689A with its LXXLL motif 2 mutated and with its LXXLL motif 1 3 retained ) from __NODE__ protein and a protein protein complex consisting of __NODE__ and of __NODE__ and vitamin D .