In cell free system , binding of a DNA fragment ( 5 ' GGGTTTGACCTTTCTCTCCGGGTAAAGGTGAAGG 3 ' containing a NRRE 1 from __SP__ __NODE__ gene and a protein protein complex consisting of __SP__ __NODE__ and of __SP__ __NODE__ is greater than binding of a mutant DNA fragment ( G?T G?T T?C ) ( 5 ' GGGTTTGACCTTTCTCTCCGGGTAAATTCGAAGG 3 ' containing a NRRE 1 from __SP__ __NODE__ gene and a protein protein complex consisting of __SP__ __NODE__ and of __SP__ __NODE__ .