In a cell free system , binding of a protein chimera composed of a protein fragment containing a __NODE__ rich domain 1 and a __NODE__ rich domain 2 and a __NODE__ rich domain 3 and a N terminal domain from __SP__ __NODE__ protein and of a protein fragment from __NODE__ Fc region and a protein fragment ( 103 281 ) from __SP__ __NODE__ protein is the same as binding of a protein chimera composed of a protein fragment containing a __NODE__ rich domain 1 and a __NODE__ rich domain 2 and a __NODE__ rich domain 3 from __SP__ __NODE__ protein and of a protein fragment from __NODE__ Fc region and of a protein fragment containing a N terminal domain from __SP__ __NODE__ protein and a protein fragment ( 103 281 ) from __SP__ __NODE__ protein .